By Pier Paolo Pandolfi (Editor), Peter K. Vogt (Editor)
Over the last 10 years, paintings on acute promyelocytic leukemia (APL) has develop into the paradigm of translational examine that all started with the invention of a recurrent chromosomal translocation, by way of the id of the genes and proteins concerned, discovering their molecular services in transcriptional keep an eye on, developing mouse versions and culminating within the improvement of designated treatment.
Read or Download Acute Promyelocytic Leukemia: Molecular Genetics, Mouse Models and Targeted Therapy (Current Topics in Microbiology and Immunology 313) PDF
Best microbiology books
The sequencing of a number of fungi genomes has spurred significant advances within the box. Fungal genomics has been having a pivotal impression on utilized examine in agriculture, nutrition sciences, ordinary source administration, prescribed drugs, and biotechnology, in addition to to simple reviews within the existence sciences. This quantity covers intriguing new advancements during this progress box, from genomic research to human fungal pathogen genomics, comparative genomics of fungi, and the genomics of fungal improvement.
Prepared in A-to-Z order, the greater than 17,000 entries offer simple information regarding primary, physiochemical legislation, chemical substances, constants, and formulae. The Dictionary additionally describes the fundamental positive factors of a few 2,000 enzymes and proteins, the reactions they catalyze and the features they practice.
Freshwater Algae: id and Use as Bioindicators presents a complete advisor to temperate freshwater algae, with additional info on key species with regards to environmental features and implications for aquatic management. The publication uniquely combines functional fabric on recommendations and water caliber administration with simple algal taxonomy and the position of algae as bioindicators.
A needs to learn for getting to know crucial thoughts in microbiologyWell-known and widespread for his or her hallmark illustrations, Lippincott’s Illustrated reports carry innovations to bright existence. scholars depend on LIR for speedy assessment, more uncomplicated assimilation, and knowing of huge quantities of serious, complicated fabric.
- Neurobiology of the Parental Brain
- Signalling Networks in Cell Shape and Motility (Novartis Foundation Symposium 269)
- Handbook of Molecular Microbial Ecology I: Metagenomics and Complementary Approaches
- Bacterial Adhesion to Host Tissues: Mechanisms and Consequences (Advances in Molecular and Cellular Microbiology)
- An Epidemic of Absence: A New Way of Understanding Allergies and Autoimmune Diseases
- The spectrum of neuro-AIDS disorders : pathophysiology, diagnosis, and treatment
Additional resources for Acute Promyelocytic Leukemia: Molecular Genetics, Mouse Models and Targeted Therapy (Current Topics in Microbiology and Immunology 313)
D. Licht Summary The study of the t(11;17)-associated forms of APL and the PLZF protein has served as a paradigm for the role that aberrant transcriptional repression plays in hematological malignancy. The resistant phenotype of t(11;17) APL can be explained in part by a gain-of-function mutation of RARα in which the protein becomes a constitutive repressor of key genes required for normal myeloid maturation. However, closer study of PLZF has revealed additional layers of complexity in the development of APL.
Biochem Biophys Res Commun 264:789–795 50. Long JJ, Leresche A, Kriwacki RW, Gottesfeld JM (1998) Repression of TFIIH transcriptional activity and TFIIH-associated cdk7 kinase activity at mitosis. Mol Cell Biol 18:1467–1476 51. Look AT (1997) Oncogenic transcription factors in the human acute leukemias. Science 278:1059–1064 52. Martin PJ, Delmotte MH, Formstecher P, Lefebvre P (2003) PLZF is a negative regulator of retinoic acid receptor transcriptional activity. Nucl Recept 1:6 53.
Only in this in vivo context can hypotheses about pathogenesis be deﬁnitively proved or refuted. Furthermore, animal models of APL are equally important for assessing ideas regarding the value of novel therapies. As we learn more about APL, added questions are raised. Among the areas that animal models will be used for in the coming years are: 1. Developing a better understanding of the cells from which relapses arise in APL and other AMLs. ) 2. Identifying the critical transcriptional targets repressed by X-RARα proteins.