Anaerobic Infections: Diagnosis and Management by Itzhak Brook

By Itzhak Brook

With new infectious brokers, antibiotics, and cases of antimicrobial resistance continually at the horizon, this box is an ever growing to be self-discipline that calls for consistent vigilance. This ebook responds to burgeoning development within the box and offers a entire and specialist armamentarium of directions for the therapy and analysis of the whole breadth of grownup and pediatric anaerobic infections.

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Paraputrificum, Clostridium perfringens, and the toxin of C. difficile have been implicated in the pathogenesis of necrotizing enteritis (59). Whether these organisms are primary pathogens or secondary invaders of an otherwise damaged intestinal mucosa remains unclear. However, 22 Anaerobic Infections it can be postulated that bottle-fed infants, especially those receiving an iron supplement, are at a greater risk for developing necrotizing enteritis caused by C. butyricum, C. difficile, and C. paraputrificum than are breast-fed infants in cases of damaged intestinal mucosa.

Gronlund et al. (47) found that fecal colonization of infants born by cesarean delivery is delayed and their gut flora may be disturbed for up to six months after the birth. Colonization rates by Bifidobacterium and Lactobacillus spp. reached the rates of vaginally delivered infants at 30 and 10 days, respectively. Infants born by cesarean delivery are less often colonized with bacteria of the B. 009). The clinical relevance of these changes is, however, unknown. Bennet and Nord (48) illustrated that there are no major differences in the gut flora of normal full-term newborn infants and preterm infants during intensive or intermediate care.

Brook I. Bacterial interference. Crit Rev Microbiol 1999; 25:155–72. 4. Brook I, Frazier EH. Aerobic and anaerobic bacteriology of wounds and cutaneous abscesses. Arch Surg 1990; 125:1445–51. 5. Evans CA, Smith WM, Johnson EA, Gilbert ER. Bacterial flora of the normal human skin. J Invest Dermatol 1950; 15:305–24. 6. McGinley KJ, Webster GF, Ruggieri MR, Leyden JJ. Regional variation in density of cutaneous Propionibacterium: correlation of Propionbacterium acnes populations with sebaceous secretions.

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